Andrographolide

Andrographolide nigicuruzwa cyibimera gikurwa mubyatsi biboneka mubushinwa.Icyatsi gifite amateka menshi yo gukoresha muri TCM mu kuvura indwara zandurira mu myanya y'ubuhumekero n'izindi ndwara zanduza kandi zanduza.Andrographis paniculata yatangijwe kandi ihingwa muri Guangdong no mu majyepfo ya Fujian mu myaka ya za 50.Ikoreshwa mu kuvura indwara zitandukanye zanduza no kurumwa n'inzoka.Mu myaka yashize, ubushakashatsi bwakozwe mu Bushinwa, ubuhinzi, imiti, imiti n’ubuvuzi bwa Andrographis paniculata.Andrographis paniculata nubuvuzi gakondo bwubushinwa, bufite ingaruka zo gukuraho ubushyuhe nuburozi, gukonjesha amaraso no kwangirika.Mubuvuzi, bukoreshwa cyane cyane mukuvura indwara zubuhumekero, acute bacillary dysentery, gastroenteritis, ubukonje, umuriro na hypertension.Hamwe no kwiyongera kwa antibiyotike no gufata nabi, ijwi ryo guteza imbere imiti gakondo yubushinwa hamwe na antibacterial nziza.Andrographis paniculata, nkumuti gakondo wubushinwa ufite antibacterial, witabiriwe cyane ninganda zimiti

Andrographis paniculata ikuramo ibimera bizwiho kugira ibikorwa bitandukanye bya farumasi.Andrographolide, igice kinini cyibikomokaho bifitanye isano nibikorwa bya farumasi.Twize inzira ya selile hamwe nintego zahinduwe nubuvuzi bwa andrographolide muri kanseri yabantu hamwe ningirabuzimafatizo.Kuvura Andrographolide byabujije ikwirakwizwa rya vitro kumirongo itandukanye yibibyimba, byerekana ubwoko bwa kanseri zitandukanye.Uru ruganda rukora ibikorwa bya anticancer kuri selile ya kanseri ifatwa na selile ya G0 / G1 binyuze mu kwinjiza poroteyine p27 no kugabanya imvugo ya kinase iterwa na kinase 4 (CDK4).Igikorwa cyo gukingira indwara ya andrographolide kigaragazwa no kwiyongera kwa lymphocytes no gukora interleukin-2.Andrographolide kandi yazamuye ibibyimba biterwa na alufa no kwerekana ibimenyetso bya CD, bigatuma ibikorwa bya cytotoxique byitwa lymphocytes birwanya kanseri ya kanseri, bishobora kugira uruhare mubikorwa bya antikanseri itaziguye.Mubikorwa bya vivo anticancer yibikorwa byongeye gushimangirwa na B16F0 melanoma syngenic na HT-29 xenograft.Ibisubizo byerekana ko andrographolide ari farumasi ishimishije hamwe na anticancer hamwe nibikorwa byo gukingira indwara bityo bikaba bifite ubushobozi bwo kwiteza imbere nka kanseri ivura kanseri.